Glucophage (metformin) is an oral diabetes medicine that helps control blood sugar levels.
What is the purpose of Glucophage?
This is a hypoglycemic (sugar-lowering) drug. It lowers the level of glycated hemoglobin, blood glucose (after meals and on an empty stomach), increases glucose tolerance. It reduces the production of glucose in the liver, increases tissue insulin sensitivity (increases the absorption of glucose and its metabolism). It does not affect the production of insulin by the pancreas. In addition, it normalizes fat metabolism.
How long does Glucophage take to work?
This is a quick-acting oral medication—you will typically see improvement within 48 hours of starting the treatment. The maximum effect will take about 4-5 days, but that depends on the dose.
Is Glucophage and metformin the same thing?
Metformin is the generic name for Glucophage. So the answer is yes, these are medications with the same composition, efficiency, indications, contraindications, side effects, etc. They can replace each other. The major difference is that the generic version costs much less.
When should Glucophage be taken?
The drug is prescribed for type II diabetes mellitus (especially in the case of concomitant obesity) if diet therapy is ineffective.
Does metformin reduce weight?
The medicine may help people with diabetes to lose weight by lowering their appetites.
Does it affect you sexually?
Metformin leads to a significant reduction in testosterone levels, sex drive and may cause low testosterone-induced erectile dysfunction. The patient’s condition improves as soon as you cancel the medicine.
Does the drug affect kidneys?
Metformin does not cause kidney damage. The kidneys process and clear the medicine out of your system via urine. If your kidneys are functioning poorely, the drug can build up in your system and cause lactic acidosis – when there is a dangerous amount of lactic acid in the body.
Who should not take Glucophage?
Contraindications for use include:
- hypersensitivity (intolerance to components);
- kidney pathology or renal insufficiency (with a creatinine level of more than 0.132 mmol / l – in men or 0.123 mmol / l – in women);
- a pronounced violation of the functional state of the liver;
- conditions accompanied by hypoxia (lack of oxygen), incl. heart and respiratory failure, acute phase of myocardial infarction, anemia, acute cerebrovascular accident);
- infectious diseases;
- extensive operations and injuries;
- chronic alcoholism;
- acute / chronic metabolic acidosis, including diabetic ketoacidosis, lactic acidosis;
- a low-calorie diet (less than 1000 kcal / day);
- research using radioactive isotopes of iodine;
With caution, the drug is prescribed for elderly people (over 65 years old), children, people performing heavy physical work (there is a risk of lactic acidosis).
What should you not eat when taking metformin?
Avoid drinking alcohol while on metformin. Drinking alcohol while taking metformin increases your risk of developing low blood sugar or lactic acidosis. You should avoid eating high-fiber foods after taking this drug.
Pregnancy and breastfeeding
Taking these tablets during pregnancy is possible if the expected therapeutic effect outweighs the risk to the fetus. The US Food and Drug Administration (FDA) places metformin in category B.
Breastfeeding should be discontinued during treatment.
How to take Glucophage?
The drug is taken orally (by mouth) during or after meals.
The starting dose is 500-850 mg 2-3 times a day.
After 10-15 days, the dose is adjusted according to the results of the glycemic profile.
The maximum recommended dose is 3000 mg per day, divided into 3 doses.
The initial dose for children over 10 years old is 500-850 mg once a day, the maximum dose is 2000 mg / day, divided into 2-3 doses.
Can I overdose on metformin?
An overdose can cause an attack of hypoglycemia, which can result in a coma (a sharp drop in blood glucose levels to a critical level).
Symptoms of hypoglycemia: tachycardia, trembling in the limbs, increased sweating, blurred consciousness. In this case, immediately give the patient a sugar solution; in case the patient has lost consciousness, inject a glucose solution intravenously. After regaining consciousness, feed the patient with food with a high glycemic index.
The patient can also experience lactic acidosis. Its symptoms are nausea, vomiting, weakness, rapid breathing, muscle pain, loss of consciousness.
Consumption of alcohol increases the risk of developing hypoglycemia and lactic acidosis.
What are the side effects of Glucophage tablets?
- Digestive disorders: lack of appetite, diarrhea, nausea, abdominal pain, vomiting;
- Metabolic disorders: lactic acidosis, hypovitaminosis B12, megaloblastic anemia;
- Neurological disorders: taste disturbance;
- Hepatobiliary disorders: liver dysfunction, hepatitis;
- Changes in the skin, subcutaneous tissue: erythema, itching, urticaria.
Does metformin make you sleepy?
If you take too much metformin you may feel sleepy. These may be early signs of a serious condition called lactic acidosis.
How to store the medicine?
Store the tablets at a temperature not exceeding 25 ° C. The expiration date is indicated on the packaging (3 years). Do not take expired tablets.