Micronase (glibenclamide) is an oral antidiabetic medication that helps control blood sugar levels.
How does it work?
This is a sugar and cholesterol-lowering agent. It specifically stimulates cells of the beta islet apparatus, increasing the production of insulin by the pancreas. Its activity is manifested with the preserved insulin-synthetic function of the gland. The drug restores the normal sensitivity of beta cells to blood sugar levels. It potentiates the effect of insulin (both endogenous and exogenous), increasing the number of receptors. It restores post-receptor signal transduction, improves insulin-receptor interaction.
What is Micronase used for?
This drug is used in the treatment of type II diabetes mellitus, if diet therapy, exercise or therapy with other oral hypoglycemic drugs does not give the expected effect.
What is the other name for glibenclamide?
Glibenclamide is also known as glyburide.
Who should not take Micronase?
Do not use this drug if you have any of the following conditions:
- increased sensitivity to sulfanilamide drugs, thiazide diuretics;
- diabetic precomatose / coma;
- extensive burns;
- surgery, trauma;
- intestinal obstruction;
- paresis of the stomach;
- conditions accompanied by impaired absorption of food;
- type I diabetes mellitus;
- hypo- / hyperthyroidism;
- liver / kidney dysfunction;
- pregnancy / lactation.
Can I use glibenclamide when pregnant?
Pregnancy Category: C (studies on animals have revealed a negative effect on the fetus, however, proper studies have not been carried out in women).
Stop breastfeeding if you are taking this medicine.
How to take Micronase?
Take the drug orally in one or two doses (30 minutes before meals).
The standard initial dose is 2.5-5 mg / day. If necessary, it is increased to 10-15 mg / day. The maximum daily dose is 20 mg.
Once glycemia is normalized, take 2.5-5 mg / day.
Can I overdose on glibenclamide?
Overdose symptoms: hypoglycemia (a feeling of hunger, anxiety, severe weakness, headache, dizziness, palpitations, sweating, muscle tremors, speech and vision disorders, brain edema, impaired consciousness, the development of hypoglycemic coma).
Therapeutic measures: in mild cases – taking sugar (sweet tea, juice, honey, syrup); in severe cases – intravenous administration of 40% glucose solution, continuous infusion of 5–10% dextrose solution, intramuscular administration of glucagon (1–2 mg), oral administration of 200 mg of diazoxide every 4 hours or 30 mg intravenously for 30 minutes; with cerebral edema – the introduction of mannitol, dexamethasone. Monitor every 15 minutes: glycemia, creatinine, pH, urea nitrogen, and blood electrolytes.
What are the most common adverse effects of Micronase?
- Hematological disorders: thrombocytopenia, erythrocytopenia, granulocytopenia, pancytopenia, leukocytopenia, eosinophilia, agranulocytosis, hemolytic or hypoplastic anemia;
- Neurological disorders: headache, change in taste, dizziness;
- Metabolic disorders: hypoglycemia, late cutaneous porphyria, proteinuria;
- Gastrointestinal disorders: cholestasis, liver dysfunction, dyspepsia.
- Allergic reactions: photosensitivity, rashes (erythema, exfoliative dermatitis);
- Others: polyuria, fever, arthralgia, weight gain.
How to store the medicine?
Store Micronase in its original packaging at temperatures not exceeding 25° C.
The drug is valid for three years after manufacture.