Generic Monoket (isosorbide mononitrate) is a medication used for heart-related chest pain, heart failure, and esophageal spasms.
How does it work?
Isosorbide mononitrate is a medicine used in cardiology. The drug causes vasodilation, relaxation of vascular smooth muscle fibers. It simultaneously expands the peripheral arteries and veins, which helps to increase the capacity of the vessels, reduce the ventricular end-diastolic pressure, preload, and reduce venous return to the heart. The dilation of arterial vessels reduces afterload, which facilitates the work of the heart. It reduces myocardial oxygen demand, causes a redistribution of blood flow in the subendocardial regions in conditions when the coronary blood flow is reduced due to damage by atherosclerotic plaques.
Is isosorbide a nitrate?
Yes, isosorbide mononitrate is a nitrate that dilates blood vessels, making it easier for blood to flow through them and easier for the heart to pump. The medicine is used to prevent angina attacks.
When should I take Monoket?
The drug is used to:
- treat congestive heart failure;
- prevent angina pectoris.
Who should not use Monoket?
The drug is not recommended for use in any of the following conditions:
- intolerance to auxiliary components;
- cerebral hemorrhage;
- allergy to isosorbide mononitrate;
- severe arterial hypotension;
- acute circulatory failure;
- acute myocardial infarction with low pressure of ventricular filling;
- severe anemia;
- pregnancy, breastfeeding;
- a recent traumatic brain injury;
Can I take isosorbide mononitrate when pregnant?
The drug can affect the hemodynamics of the fetus, therefore, its use during pregnancy is contraindicated.
Breastfeeding should be stopped before you start treatment.
How to take Monoket?
The medicine is taken orally before meals, with water.
The daily dose varies from 20 mg to 120 mg (maximum), divided into three doses depending on the severity of the disease.
The standard dose for the prevention of angina pectoris is 20 mg 2-3 times a day.
To achieve the maximum therapeutic effect, the individual dosage is recommended.
Can I overdose on isosorbide mononitrate?
Overdose symptoms: drop in blood pressure, sweating, dizziness when standing up, pallor, weak pulse, tachycardia, vomiting, convulsions, headache, weakness, methemoglobinemia, intracranial hypertension, visual disturbances.
Treatment of an overdose includes gastric lavage, the intake of enterosorbents. The patient is placed on a bed, symptomatic therapy is prescribed, oxygen is supplied. For severe reactions, dopamine, sympathomimetic agents are used.
With methemoglobinemia, doctors prescribe a 1% solution of methylene blue, artificial ventilation of the lungs, hemodialysis, and re-placement blood transfusion.
What are the side effects of Monoket?
- Neurological disorders: drowsiness, dizziness, headache;
- Gastrointestinal disorders: abdominal discomfort, nausea, vomiting;
- Cardiovascular disorders: reflex tachycardia, arterial hypotension, symptomatic palpitation, bradycardia, collapse, rhythm disturbance;
- General disorders: hypersensitivity (including anaphylactic shock, allergic dermatitis, skin rashes, itching, urticaria), dilatation of skin vessels with redness, weakness.
How to store the medicine?
Store isosorbide mononitrate medication at temperatures not exceeding +25 ° C.
Do not use the expired drug. The expiration date is indicated on the package.